| 1. Round | 18/07/2016 | Santos Laguna | - | UANL Tigres | 0:0 | ||||
| 2. Round | 23/07/2016 | CD Veracruz | - | Santos Laguna | 2:0 | ||||
| 4. Round | 08/08/2016 | Puebla FC | - | Santos Laguna | 0:0 | ||||
| 5. Round | 15/08/2016 | Santos Laguna | - | Deportivo Guadalajara | 0:1 | ||||
| 9. Round | 19/09/2016 | Santos Laguna | - | Pumas UNAM | 3:1 | ||||
| 10. Round | 22/09/2016 | CF Monterrey | - | Santos Laguna | 5:2 | ||||
| 12. Round | 01/10/2016 | Gallos Blancos | - | Santos Laguna | 1:1 | ||||
| 16. Round | 07/11/2016 | Santos Laguna | - | Chiapas FC | 2:0 | ||||
| 17. Round | 20/11/2016 | Deportivo Toluca | - | Santos Laguna | 1:2 |
Mexico