| 1. Round | 22/07/2017 | Lobos BUAP | - | Santos Laguna | 2:2 | ||||
| 2. Round | 31/07/2017 | Santos Laguna | - | UANL Tigres | 1:1 | ||||
| 3. Round | 05/08/2017 | Monarcas Morelia | - | Santos Laguna | 1:1 |  |
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| 4. Round | 14/08/2017 | Santos Laguna | - | CD Veracruz | 2:3 | ||||
| 5. Round | 19/08/2017 | Club Tijuana | - | Santos Laguna | 2:0 | ||||
| 6. Round | 24/08/2017 | Santos Laguna | - | Deportivo Guadalajara | 1:1 | ||||
| 7. Round | 27/08/2017 | Club León | - | Santos Laguna | 1:2 | |
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| 8. Round | 11/09/2017 | Santos Laguna | - | Deportivo Toluca | 0:0 | ||||
| 9. Round | 16/09/2017 | Cruz Azul | - | Santos Laguna | 2:1 | ||||
| 12. Round | 02/10/2017 | Santos Laguna | - | Puebla FC | 0:0 |  |
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| 13. Round | 16/10/2017 | Santos Laguna | - | Atlas Guadalajara | 0:1 | ||||
| 10. Round | 19/10/2017 | Santos Laguna | - | Club Necaxa | 3:2 | ||||
| 14. Round | 21/10/2017 | Gallos Blancos | - | Santos Laguna | 1:2 | ||||
| 15. Round | 30/10/2017 | Santos Laguna | - | CF Pachuca | 2:2 | ||||
| 11. Round | 10/11/2017 | CF Monterrey | - | Santos Laguna | 1:1 |
Mexico