| 1. Round | 02/07/2022 | Deportivo Guadalajara [U18] | - | FC Juárez [U18] | 1:0 | ||||
| 3. Round | 05/07/2022 | Santos Laguna [U18] | - | Deportivo Guadalajara [U18] | 3:1 | ||||
| 2. Round | 09/07/2022 | Deportivo Guadalajara [U18] | - | Atlético San Luis [U18] | 3:1 | ||||
| 10. Round | 09/08/2022 | Club Necaxa [U18] | - | Deportivo Guadalajara [U18] | 1:2 | ||||
| 8. Round | 13/08/2022 | Deportivo Guadalajara [U18] | - | Atlas Guadalajara [U18] | 0:1 | ||||
| 11. Round | 27/08/2022 | Deportivo Guadalajara [U18] | - | Pumas UNAM [U18] | 1:0 | ||||
| 12. Round | 04/09/2022 | Deportivo Toluca [U18] | - | Deportivo Guadalajara [U18] | 1:0 | ||||
| 13. Round | 07/09/2022 | Club Tijuana [U18] | - | Deportivo Guadalajara [U18] | 1:0 | ||||
| 14. Round | 10/09/2022 | Deportivo Guadalajara [U18] | - | Puebla FC [U18] | 1:1 |  |
|||
| 9. Round | 13/09/2022 | Deportivo Guadalajara [U18] | - | UANL Tigres [U18] | 2:2 |  |
|||
| 15. Round | 17/09/2022 | CF América [U18] | - | Deportivo Guadalajara [U18] | 0:3 | ||||
| 16. Round | 28/09/2022 | Deportivo Guadalajara [U18] | - | CF Monterrey [U18] | 4:0 |
Mexico