| 7. Round | 09/10/2010 | Miramar Misiones | - | Defensor Sporting | 0:1 |  |
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| 9. Round | 24/10/2010 | Defensor Sporting | - | Rampla Juniors | 4:1 | ||||
| 11. Round | 06/11/2010 | Racing | - | Defensor Sporting | 0:3 | ||||
| 12. Round | 13/11/2010 | Defensor Sporting | - | Central Español | 1:1 | ||||
| 13. Round | 20/11/2010 | Peñarol | - | Defensor Sporting | 0:1 |
Uruguay