| 12. Round | 16/09/2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 13. Round | 22/09/2021 | Central Español | - | Rocha | 1:0 | ||||
| 16. Round | 13/10/2021 | Rocha | - | Villa Teresa | 1:1 | ||||
| 18. Round | 27/10/2021 | Rocha | - | Uruguay Montevideo | 1:2 |  |
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| 19. Round | 01/11/2021 | Rampla Juniors | - | Rocha | 2:1 | ||||
| 22. Round | 24/11/2021 | CA Cerro | - | Rocha | 3:0 |
Uruguay