| 1. Round | 30/04/2022 | Villa Española | - | Rampla Juniors | 3:2 |  |
|||
| 2. Round | 07/05/2022 | Progreso | - | Villa Española | 2:0 | ||||
| 3. Round | 15/05/2022 | Villa Española | - | La Luz | 1:1 | ||||
| 4. Round | 20/05/2022 | Atenas | - | Villa Española | 2:3 | ||||
| 5. Round | 24/05/2022 | Villa Española | - | CA Cerro | 0:1 | ||||
| 6. Round | 28/05/2022 | Sud América | - | Villa Española | 2:0 | ||||
| 7. Round | 04/06/2022 | Villa Española | - | Central Español | 2:1 | ||||
| 8. Round | 12/06/2022 | Miramar Misiones | - | Villa Española | 1:0 |  |
|||
| 9. Round | 19/06/2022 | Uruguay Montevideo | - | Villa Española | 1:3 | |
|||
| 10. Round | 22/06/2022 | Villa Española | - | Juventud de Las Piedras | 1:1 | |
|||
| 11. Round | 26/06/2022 | Racing | - | Villa Española | 3:2 | |
Uruguay