| 5. Round | 25/08/2024 | Club León | - | Santos Laguna | 1:1 | ||||
| 6. Round | 31/08/2024 | Club Tijuana | - | Club León | 2:1 |  |
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| 7. Round | 15/09/2024 | Club León | - | Cruz Azul | 1:2 | |
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| 8. Round | 19/09/2024 | Deportivo Guadalajara | - | Club León | 2:0 | ||||
| 9. Round | 22/09/2024 | Club León | - | Atlético San Luis | 1:0 | ||||
| 10. Round | 28/09/2024 | UANL Tigres | - | Club León | 2:2 | ||||
| 11. Round | 06/10/2024 | Club León | - | CF América | 1:1 | ||||
| 12. Round | 20/10/2024 | FC Juárez | - | Club León | 2:3 |  |
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| 13. Round | 24/10/2024 | Club León | - | Atlas Guadalajara | 0:0 | ||||
| 14. Round | 27/10/2024 | Club León | - | Gallos Blancos | 4:0 | |
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| 15. Round | 02/11/2024 | Deportivo Toluca | - | Club León | 2:2 | ||||
| 16. Round | 06/11/2024 | Club León | - | Mazatlán FC | 0:0 | |
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| 17. Round | 11/11/2024 | CF Monterrey | - | Club León | 2:1 |
Uruguay