| 4. Round | 14/08/2021 | Club León [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 5. Round | 18/08/2021 | Deportivo Guadalajara [U20] | - | Club León [U20] | 1:2 | ||||
| 6. Round | 21/08/2021 | Club León [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 8. Round | 11/09/2021 | UANL Tigres [U20] | - | Club León [U20] | 2:0 | ||||
| 9. Round | 18/09/2021 | Club León [U20] | - | FC Juárez [U20] | 2:0 | ||||
| 11. Round | 03/11/2021 | Cruz Azul [U20] | - | Club León [U20] | 2:0 |  |
Mexico