| 2. Round | 18/01/2025 | Santiago FC | - | CD Ayense | 3:2 | ||||
| 5. Round | 07/02/2025 | Santiago FC | - | Artesanos Metepec | 3:0 | ||||
| 6. Round | 14/02/2025 | Real Zamora | - | Santiago FC | 1:2 | ||||
| 8. Round | 01/03/2025 | Club de Ciervos | - | Santiago FC | 0:3 | ||||
| 9. Round | 08/03/2025 | Santiago FC | - | CDM FC | 1:1 | ||||
| 13. Round | 05/04/2025 | Santiago FC | - | Cañoneros FC | 2:1 |
Mexico