| 1. Round | 23/01/2016 | Club Nacional | - | Guaraní | 2:1 | ||||
| 2. Round | 29/01/2016 | Club Rubio Ñu | - | Club Nacional | 2:1 |  |
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| 3. Round | 03/02/2016 | Club Nacional | - | Club Olimpia | 2:2 | ||||
| 4. Round | 08/02/2016 | Sol de América | - | Club Nacional | 4:3 | ||||
| 5. Round | 14/02/2016 | Club Nacional | - | Libertad | 1:3 | ||||
| 6. Round | 20/02/2016 | Club Nacional | - | River Plate | 0:0 |
Paraguay