| 2. Round | 23/07/2018 | Independiente CG | - | Club Nacional | 2:2 | ||||
| 3. Round | 29/07/2018 | Club Nacional | - | General Díaz | 1:1 | ||||
| 4. Round | 05/08/2018 | Guaraní | - | Club Nacional | 1:1 | ||||
| 9. Round | 11/09/2018 | Club Nacional | - | Deportivo Capiatá | 3:1 | ||||
| 10. Round | 16/09/2018 | 3 de Febrero | - | Club Nacional | 1:3 | ||||
| 11. Round | 23/09/2018 | Club Nacional | - | Cerro Porteño | 0:3 |  |
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| 16. Round | 29/10/2018 | Deportivo Santaní | - | Club Nacional | 3:0 | ||||
| 18. Round | 12/11/2018 | Sportivo Luqueño | - | Club Nacional | 1:1 | |
Paraguay