| 4. Round | 10/04/2021 | Always Ready | - | Nacional Potosí | 1:1 |  |
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| 5. Round | 24/04/2021 | Nacional Potosí | - | Royal Pari | 2:1 | |
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| 6. Round | 02/05/2021 | Real Potosí | - | Nacional Potosí | 1:2 |  |
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| 7. Round | 09/05/2021 | Nacional Potosí | - | CD Guabirá | 2:1 | ||||
| 8. Round | 13/07/2021 | Blooming | - | Nacional Potosí | 2:1 | ||||
| 10. Round | 20/07/2021 | Club Aurora | - | Nacional Potosí | 0:0 | ||||
| 11. Round | 24/07/2021 | Nacional Potosí | - | Real Tomayapo | 0:0 | ||||
| 23. Round | 24/10/2021 | Nacional Potosí | - | Blooming | 4:0 | ||||
| 24. Round | 28/10/2021 | Bolívar | - | Nacional Potosí | 4:2 | ||||
| 26. Round | 23/11/2021 | Real Tomayapo | - | Nacional Potosí | 3:0 | ||||
| 27. Round | 26/11/2021 | Nacional Potosí | - | Club San José | 7:1 | |
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| 28. Round | 01/12/2021 | Real Santa Cruz | - | Nacional Potosí | 1:1 | |
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| 29. Round | 05/12/2021 | Independiente Petrolero | - | Nacional Potosí | 2:0 |
Bolivia