| 1. Round | 05/02/2022 | Nacional Potosí | - | Atlético Palmaflor | 1:1 | ||||
| 2. Round | 12/02/2022 | Universitario de Sucre | - | Nacional Potosí | 4:3 |  |
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| 3. Round | 18/02/2022 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
| 5. Round | 05/03/2022 | The Strongest | - | Nacional Potosí | 1:1 |  |
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| 6. Round | 13/03/2022 | Nacional Potosí | - | Real Tomayapo | 5:0 | |
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| 7. Round | 01/04/2022 | Nacional Potosí | - | Club Aurora | 2:1 | ||||
| 8. Round | 10/04/2022 | Oriente Petrolero | - | Nacional Potosí | 4:2 | ||||
| 9. Round | 17/04/2022 | Atlético Palmaflor | - | Nacional Potosí | 1:0 | ||||
| 10. Round | 22/04/2022 | Nacional Potosí | - | Universitario de Sucre | 1:1 | ||||
| 11. Round | 24/04/2022 | Real Santa Cruz | - | Nacional Potosí | 3:2 | ||||
| 12. Round | 29/04/2022 | CD Guabirá | - | Nacional Potosí | 1:2 | ||||
| 13. Round | 07/05/2022 | Real Tomayapo | - | Nacional Potosí | 1:0 | ||||
| 16. Round | 21/05/2022 | Nacional Potosí | - | Oriente Petrolero | 4:2 |
Bolivia