| 1. Round | 03/07/2022 | Nacional Potosí | - | Club Aurora | 3:1 | ||||
| 6. Round | 26/07/2022 | Nacional Potosí | - | Real Santa Cruz | 3:1 |  |
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| 7. Round | 01/08/2022 | Atlético Palmaflor | - | Nacional Potosí | 0:1 |  |
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| 8. Round | 07/08/2022 | Nacional Potosí | - | Bolívar | 2:1 | ||||
| 9. Round | 12/08/2022 | Universitario de Sucre | - | Nacional Potosí | 0:1 | ||||
| 10. Round | 14/08/2022 | Nacional Potosí | - | Jorge Wilstermann | 1:0 | ||||
| 13. Round | 29/08/2022 | Oriente Petrolero | - | Nacional Potosí | 4:0 | ||||
| 14. Round | 01/09/2022 | Nacional Potosí | - | Real Tomayapo | 2:1 | |
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| 16. Round | 10/09/2022 | Club Aurora | - | Nacional Potosí | 1:5 | |
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| 17. Round | 13/09/2022 | Nacional Potosí | - | Always Ready | 1:1 | ||||
| 18. Round | 17/09/2022 | The Strongest | - | Nacional Potosí | 1:1 | ||||
| 19. Round | 01/10/2022 | Nacional Potosí | - | Royal Pari | 1:0 | ||||
| 20. Round | 04/10/2022 | Nacional Potosí | - | CD Guabirá | 3:1 | ||||
| 21. Round | 08/10/2022 | Real Santa Cruz | - | Nacional Potosí | 2:1 | ||||
| 22. Round | 12/10/2022 | Nacional Potosí | - | Atlético Palmaflor | 6:1 | ||||
| 23. Round | 15/10/2022 | Bolívar | - | Nacional Potosí | 3:1 | |
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| 24. Round | 20/10/2022 | Nacional Potosí | - | Universitario de Sucre | 3:2 |
Bolivia