| 1. Round | 08/01/2022 | Deportivo Guadalajara [U16] | - | Atlético San Luis [U16] | 1:1 | ||||
| 2. Round | 15/01/2022 | CF Monterrey [U16] | - | Deportivo Guadalajara [U16] | 2:2 |  |
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| 3. Round | 22/01/2022 | Deportivo Guadalajara [U16] | - | Club León [U16] | 2:1 | ||||
| 8. Round | 26/02/2022 | UANL Tigres [U16] | - | Deportivo Guadalajara [U16] | 1:4 | ||||
| 9. Round | 05/03/2022 | Deportivo Guadalajara [U16] | - | Atlas Guadalajara [U16] | 2:3 | ||||
| 10. Round | 12/03/2022 | Atlético San Luis [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 11. Round | 19/03/2022 | Deportivo Guadalajara [U16] | - | Club Tijuana [U16] | 2:0 |
Mexico