| 3. Round | 08/08/2021 | Pumas UNAM [U20] | - | Atlético San Luis [U20] | 5:3 | ||||
| 6. Round | 21/08/2021 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 9. Round | 16/09/2021 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 3:0 | ||||
| 10. Round | 26/09/2021 | Deportivo Toluca [U20] | - | Atlético San Luis [U20] | 2:0 |
Mexico