| 1. Round | 01/07/2022 | Club Necaxa [U20] | - | Deportivo Toluca [U20] | 6:1 | ||||
| 5. Round | 26/07/2022 | Club León [U20] | - | Deportivo Toluca [U20] | 0:0 | ||||
| 8. Round | 13/08/2022 | Cruz Azul [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 9. Round | 17/08/2022 | Deportivo Toluca [U20] | - | CF Monterrey [U20] | 2:0 |  |
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| 10. Round | 21/08/2022 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 5:0 | ||||
| 11. Round | 28/08/2022 | Deportivo Toluca [U20] | - | CF Pachuca [U20] | 2:3 | |
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| 12. Round | 04/09/2022 | Deportivo Toluca [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 13. Round | 07/09/2022 | UANL Tigres [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 14. Round | 10/09/2022 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 1:2 | ||||
| 15. Round | 16/09/2022 | Mazatlán FC [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 4. Round | 22/09/2022 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 1:0 |  |
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| 17. Round | 02/10/2022 | Deportivo Toluca [U20] | - | Gallos Blancos [U20] | 2:2 | |
Mexico