| 2. Round | 23/08/2015 | Nacional | - | River Plate | 2:1 | ||||
| 3. Round | 29/08/2015 | River Plate | - | Sud América | 2:0 | ||||
| 4. Round | 05/09/2015 | Montevideo Wanderers | - | River Plate | 5:1 | ||||
| 5. Round | 13/09/2015 | River Plate | - | Racing | 3:1 | ||||
| 6. Round | 20/09/2015 | Plaza Colonia | - | River Plate | 3:2 | ||||
| 7. Round | 27/09/2015 | River Plate | - | Peñarol | 4:0 | ||||
| 11. Round | 01/11/2015 | River Plate | - | Rentistas | 2:3 | ||||
| 12. Round | 06/11/2015 | El Tanque Sisley | - | River Plate | 2:1 |
Uruguay