| 12. Round | 24/09/2016 | River Plate | - | Libertad | 2:0 | ||||
| 13. Round | 30/09/2016 | General Díaz | - | River Plate | 2:0 | ||||
| 16. Round | 29/10/2016 | River Plate | - | Club Rubio Ñu | 0:2 |  |
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| 18. Round | 18/11/2016 | River Plate | - | Sportivo Luqueño | 0:2 | ||||
| 19. Round | 26/11/2016 | River Plate | - | Deportivo Capiatá | 2:4 | ||||
| 20. Round | 02/12/2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 21. Round | 10/12/2016 | River Plate | - | Sol de América | 2:4 | ||||
| 22. Round | 17/12/2016 | Club Nacional | - | River Plate | 2:0 |
Paraguay