| 1. Round | 09/01/2022 | Santos Laguna [U16] | - | CF Monterrey [U16] | 0:0 | ||||
| 3. Round | 22/01/2022 | UANL Tigres [U16] | - | Santos Laguna [U16] | 0:2 | ||||
| 4. Round | 29/01/2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 0:1 |  |
|||
| 5. Round | 04/02/2022 | Atlético San Luis [U16] | - | Santos Laguna [U16] | 2:1 | ||||
| 6. Round | 12/02/2022 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 5:3 | ||||
| 7. Round | 18/02/2022 | Club León [U16] | - | Santos Laguna [U16] | 0:0 | ||||
| 8. Round | 26/02/2022 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 2:0 | ||||
| 9. Round | 05/03/2022 | Santos Laguna [U16] | - | Club Tijuana [U16] | 2:0 | ||||
| 12. Round | 26/03/2022 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 3:1 | ||||
| 13. Round | 02/04/2022 | CF Monterrey [U16] | - | Santos Laguna [U16] | 2:1 | |
|||
| 15. Round | 20/04/2022 | Club Tijuana [U16] | - | Santos Laguna [U16] | 0:1 |  |
|||
| 16. Round | 23/04/2022 | Santos Laguna [U16] | - | UANL Tigres [U16] | 5:0 | ||||
| 17. Round | 30/04/2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 3:0 | |
|||
| 18. Round | 07/05/2022 | Santos Laguna [U16] | - | Club León [U16] | 2:1 |
Mexico