| 2. Round | 20/01/2025 | CF Pachuca [U19] | - | Santos Laguna [U19] | 2:1 | ||||
| 5. Round | 02/02/2025 | Santos Laguna [U19] | - | Puebla FC [U19] | 2:0 | ||||
| 7. Round | 14/02/2025 | Mazatlán FC [U19] | - | Santos Laguna [U19] | 3:0 | ||||
| 8. Round | 23/02/2025 | Santos Laguna [U19] | - | Atlas Guadalajara [U19] | 1:2 | ||||
| 10. Round | 02/03/2025 | CF Monterrey [U19] | - | Santos Laguna [U19] | 1:0 | ||||
| 11. Round | 09/03/2025 | Santos Laguna [U19] | - | Club León [U19] | 2:1 | ||||
| 12. Round | 15/03/2025 | UANL Tigres [U19] | - | Santos Laguna [U19] | 3:1 | ||||
| 15. Round | 18/03/2025 | Santos Laguna [U19] | - | Gallos Blancos [U19] | 4:2 | ||||
| 13. Round | 30/03/2025 | Santos Laguna [U19] | - | Atlético San Luis [U19] | 2:1 | ||||
| 14. Round | 06/04/2025 | Deportivo Toluca [U19] | - | Santos Laguna [U19] | 0:2 | ||||
| 17. Round | 20/04/2025 | Santos Laguna [U19] | - | Club Tijuana [U19] | 1:1 |  |
Mexico