| 1. Round | 17/07/2018 | 3 de Febrero | - | General Díaz | 1:1 |  |
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| 2. Round | 21/07/2018 | General Díaz | - | Club Olimpia | 1:1 | ||||
| 3. Round | 29/07/2018 | Club Nacional | - | General Díaz | 1:1 | ||||
| 4. Round | 05/08/2018 | Deportivo Santaní | - | General Díaz | 3:1 | ||||
| 5. Round | 10/08/2018 | General Díaz | - | Sportivo Luqueño | 2:2 | ||||
| 8. Round | 02/09/2018 | Independiente CG | - | General Díaz | 2:2 | ||||
| 9. Round | 09/09/2018 | General Díaz | - | Guaraní | 3:1 |  |
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| 10. Round | 15/09/2018 | Libertad | - | General Díaz | 1:0 |  |
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| 14. Round | 14/10/2018 | General Díaz | - | Club Nacional | 1:2 | ||||
| 18. Round | 11/11/2018 | Cerro Porteño | - | General Díaz | 3:1 | |
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| 19. Round | 18/11/2018 | General Díaz | - | Independiente CG | 2:1 | ||||
| 20. Round | 23/11/2018 | Guaraní | - | General Díaz | 0:2 | ||||
| 21. Round | 01/12/2018 | General Díaz | - | Libertad | 1:1 | ||||
| 22. Round | 08/12/2018 | Sol de América | - | General Díaz | 1:0 | |
Paraguay