| 1. Round | 05/02/2022 | 12 de Octubre de Itauguá | - | Libertad | 1:6 | ||||
| 2. Round | 12/02/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 3. Round | 20/02/2022 | Club Olimpia | - | Libertad | 2:2 |  |
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| 4. Round | 27/02/2022 | Tacuary | - | Libertad | 0:1 | ||||
| 5. Round | 06/03/2022 | Libertad | - | Sportivo Ameliano | 2:0 | ||||
| 6. Round | 14/03/2022 | Club Nacional | - | Libertad | 0:3 | ||||
| 7. Round | 20/03/2022 | Libertad | - | Guaraní | 2:0 | ||||
| 8. Round | 02/04/2022 | Guaireña FC | - | Libertad | 2:3 | ||||
| 9. Round | 10/04/2022 | Libertad | - | Sol de América | 3:1 | ||||
| 11. Round | 21/04/2022 | Libertad | - | Resistencia SC | 2:2 | ||||
| 13. Round | 30/04/2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
| 15. Round | 11/05/2022 | Libertad | - | Tacuary | 3:0 | ||||
| 16. Round | 15/05/2022 | Sportivo Ameliano | - | Libertad | 1:3 | ||||
| 17. Round | 23/05/2022 | Libertad | - | Club Nacional | 1:0 | ||||
| 18. Round | 14/06/2022 | Guaraní | - | Libertad | 1:1 | ||||
| 19. Round | 18/06/2022 | Libertad | - | Guaireña FC | 2:0 | ||||
| 20. Round | 21/06/2022 | Sol de América | - | Libertad | 0:3 | ||||
| 21. Round | 26/06/2022 | Libertad | - | Cerro Porteño | 1:0 |
Paraguay