| 1. Round | 16/07/2022 | Sportivo Ameliano | - | Libertad | 2:0 | ||||
| 2. Round | 20/07/2022 | Libertad | - | Club Olimpia | 4:2 | ||||
| 3. Round | 24/07/2022 | General Caballero DJLM | - | Libertad | 3:2 | ||||
| 7. Round | 21/08/2022 | Club Nacional | - | Libertad | 0:2 | ||||
| 8. Round | 27/08/2022 | Libertad | - | Guaraní | 2:2 | ||||
| 16. Round | 09/10/2022 | Libertad | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 13. Round | 12/10/2022 | Club Olimpia | - | Libertad | 1:0 | ||||
| 17. Round | 17/10/2022 | Sol de América | - | Libertad | 1:1 | ||||
| 18. Round | 23/10/2022 | Libertad | - | Club Nacional | 0:1 | ||||
| 20. Round | 31/10/2022 | Libertad | - | Cerro Porteño | 0:0 | ||||
| 21. Round | 06/11/2022 | Libertad | - | Guaireña FC | 4:2 |  |
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| 22. Round | 12/11/2022 | Tacuary | - | Libertad | 1:0 |
Paraguay