| 1. Round | 30/01/2011 | Club Rubio Ñu | - | Sol de América | 1:0 | ||||
| 2. Round | 06/02/2011 | Sportivo Luqueño | - | Club Rubio Ñu | 2:2 | ||||
| 5. Round | 20/02/2011 | Club Rubio Ñu | - | Tacuary | 0:1 | ||||
| 6. Round | 27/02/2011 | Club Rubio Ñu | - | Club Nacional | 0:0 | ||||
| 7. Round | 04/03/2011 | Libertad | - | Club Rubio Ñu | 4:1 | ||||
| 10. Round | 19/03/2011 | Club Rubio Ñu | - | Independiente CG | 2:2 |  |
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| 4. Round | 23/03/2011 | Guaraní | - | Club Rubio Ñu | 2:1 | ||||
| 15. Round | 23/04/2011 | Club Rubio Ñu | - | Guaraní | 3:0 | ||||
| 18. Round | 08/05/2011 | Club Rubio Ñu | - | Libertad | 0:1 |
Paraguay