| 21. Round | 26/07/2022 | Deportes Iquique | - | Puerto Montt | 1:1 | ||||
| 22. Round | 31/07/2022 | CD Magallanes | - | Deportes Iquique | 1:0 | ||||
| 23. Round | 09/08/2022 | Deportes Iquique | - | Santiago Morning | 3:1 |  |
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| 24. Round | 15/08/2022 | Santa Cruz | - | Deportes Iquique | 1:0 | ||||
| 25. Round | 21/08/2022 | Deportes Iquique | - | Fernández Vial | 0:0 | ||||
| 26. Round | 31/08/2022 | Cobreloa | - | Deportes Iquique | 2:1 | ||||
| 27. Round | 07/09/2022 | Deportes Iquique | - | Deportes Copiapó | 0:0 | ||||
| 28. Round | 12/09/2022 | Rangers | - | Deportes Iquique | 0:2 | ||||
| 29. Round | 25/09/2022 | Deportes Iquique | - | Universidad de Concepción | 1:2 | ||||
| 30. Round | 04/10/2022 | San Luis | - | Deportes Iquique | 0:0 | |
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| 31. Round | 10/10/2022 | Deportes Iquique | - | Barnechea | 0:2 | ||||
| 32. Round | 16/10/2022 | Recoleta | - | Deportes Iquique | 3:0 | ||||
| 33. Round | 22/10/2022 | Deportes Iquique | - | Unión San Felipe | 3:0 | ||||
| 34. Round | 01/11/2022 | Deportes Melipilla | - | Deportes Iquique | 0:0 |
Chile