| 3. Round | 26/09/2021 | Apollon Lárissa | - | AE Lárissa | 0:3 | ||||
| 4. Round | 06/10/2021 | Diagoras FC | - | AE Lárissa | 1:2 aet |  |
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| 5. Round | 26/10/2021 | AE Lárissa | - | PAS Giannina | 3:1 pso | |
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| Round of 16 | 01/12/2021 | AE Lárissa | - | PAOK Saloniki | 1:1 | ||||
| Round of 16 | 22/12/2021 | PAOK Saloniki | - | AE Lárissa | 3:1 |
Greece