| 17. Round | 05/02/2022 | Panathinaikos II | - | AO Episkopi | 1:2 | ||||
| 13. Round | 09/02/2022 | Panathinaikos II | - | AO Egaleo | 0:1 | ||||
| 18. Round | 12/02/2022 | Panathinaikos II | - | AE Kifisias | 1:0 | ||||
| 19. Round | 16/02/2022 | AEK Athen II | - | Panathinaikos II | 0:1 | ||||
| 20. Round | 20/02/2022 | Panathinaikos II | - | PS Kalamata | 1:2 | ||||
| 22. Round | 05/03/2022 | AE Karaiskakis | - | Panathinaikos II | 1:1 | ||||
| 23. Round | 09/03/2022 | Panathinaikos II | - | Ergotelis | 0:0 | ||||
| 24. Round | 12/03/2022 | Asteras Vlachioti | - | Panathinaikos II | 3:1 | ||||
| 25. Round | 19/03/2022 | Panathinaikos II | - | Diagoras FC | 3:0 | ||||
| 26. Round | 26/03/2022 | PAE Chania | - | Panathinaikos II | 2:0 | ||||
| 27. Round | 30/03/2022 | Panathinaikos II | - | APS Zakynthos | 1:1 |  |
Greece