| 1. Round | 26/08/2018 | Panionios GSS | - | OFI Heraklion | 2:2 |  |
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| 6. Round | 06/10/2018 | Panionios GSS | - | Aris Saloniki | 1:0 | ||||
| 14. Round | 15/12/2018 | PAS Giannina | - | Panionios GSS | 3:1 | ||||
| 16. Round | 12/01/2019 | OFI Heraklion | - | Panionios GSS | 1:1 | ||||
| 17. Round | 19/01/2019 | PAOK Saloniki | - | Panionios GSS | 3:0 | ||||
| 18. Round | 26/01/2019 | Panionios GSS | - | AEK Athen | 0:2 | ||||
| 15. Round | 30/01/2019 | Panionios GSS | - | Asteras Tripolis | 1:0 | ||||
| 19. Round | 02/02/2019 | Olympiakos Piraeus | - | Panionios GSS | 4:0 | ||||
| 20. Round | 09/02/2019 | Panionios GSS | - | Apollon Smyrnis | 0:1 | ||||
| 21. Round | 17/02/2019 | Aris Saloniki | - | Panionios GSS | 1:1 | |
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| 22. Round | 24/02/2019 | Panionios GSS | - | Panathinaikos | 2:0 | |
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| 23. Round | 03/03/2019 | Atromitos | - | Panionios GSS | 3:0 | ||||
| 24. Round | 11/03/2019 | Panetolikos | - | Panionios GSS | 5:0 | ||||
| 25. Round | 17/03/2019 | Panionios GSS | - | Xanthi FC | 1:0 | ||||
| 27. Round | 06/04/2019 | Panionios GSS | - | AE Lárissa | 1:0 | |
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| 28. Round | 14/04/2019 | Levadiakos | - | Panionios GSS | 1:2 | ||||
| 29. Round | 21/04/2019 | Panionios GSS | - | PAS Giannina | 2:1 | |
Greece