| 2. Round | 23/09/2007 | Olympiakos Piraeus | - | OFI Heraklion | 6:2 | ||||
| 3. Round | 30/09/2007 | OFI Heraklion | - | Ergotelis | 4:1 | ||||
| 4. Round | 06/10/2007 | PAOK Saloniki | - | OFI Heraklion | 2:2 | ||||
| 6. Round | 28/10/2007 | Veria FC | - | OFI Heraklion | 2:1 |  |
|||
| 7. Round | 04/11/2007 | Atromitos | - | OFI Heraklion | 1:0 | |
|||
| 8. Round | 11/11/2007 | OFI Heraklion | - | Levadiakos | 1:2 | ||||
| 9. Round | 25/11/2007 | AEK Athen | - | OFI Heraklion | 4:0 | |
|||
| 12. Round | 16/12/2007 | OFI Heraklion | - | Iraklis Saloniki | 2:0 | ||||
| 13. Round | 23/12/2007 | Panathinaikos | - | OFI Heraklion | 3:1 | |
|||
| 14. Round | 30/12/2007 | Panionios GSS | - | OFI Heraklion | 1:3 | ||||
| 15. Round | 06/01/2008 | OFI Heraklion | - | Aris Saloniki | 0:1 | ||||
| 16. Round | 13/01/2008 | Apollon Kalamarias | - | OFI Heraklion | 1:1 | ||||
| 19. Round | 03/02/2008 | OFI Heraklion | - | PAOK Saloniki | 2:0 | |
|||
| 20. Round | 10/02/2008 | Asteras Tripolis | - | OFI Heraklion | 1:1 | ||||
| 21. Round | 17/02/2008 | OFI Heraklion | - | Veria FC | 3:0 | ||||
| 23. Round | 02/03/2008 | Levadiakos | - | OFI Heraklion | 0:3 | ||||
| 24. Round | 09/03/2008 | OFI Heraklion | - | AEK Athen | 1:4 | |
Greece