| 5. Round | 31/01/2021 | Apollon Lárissa | - | Panachaiki GE | 0:3 |  |
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| 6. Round | 07/02/2021 | Panachaiki GE | - | Ionikos Nikea | 0:1 | ||||
| 7. Round | 10/02/2021 | Doxa Dramas FC | - | Panachaiki GE | 0:0 | ||||
| 8. Round | 14/02/2021 | Panachaiki GE | - | Levadiakos | 2:0 | ||||
| 10. Round | 20/02/2021 | Ergotelis | - | Panachaiki GE | 1:0 | ||||
| 14. Round | 14/03/2021 | OFI Ierapetra | - | Panachaiki GE | 1:0 | ||||
| 15. Round | 17/03/2021 | AE Karaiskakis | - | Panachaiki GE | 0:0 | ||||
| 16. Round | 20/03/2021 | Panachaiki GE | - | Apollon Lárissa | 1:0 | ||||
| 17. Round | 28/03/2021 | Ionikos Nikea | - | Panachaiki GE | 1:0 | ||||
| 18. Round | 04/04/2021 | Panachaiki GE | - | Doxa Dramas FC | 2:1 | ||||
| 19. Round | 07/04/2021 | Levadiakos | - | Panachaiki GE | 3:0 | ||||
| 22. Round | 21/04/2021 | Xanthi FC | - | Panachaiki GE | 4:0 |
Greece