| 1. Round | 15/08/2021 | Excelsior Virton | - | KVC Westerlo | 0:2 | ||||
| 2. Round | 22/08/2021 | Lierse Kempenzonen | - | Excelsior Virton | 2:0 | ||||
| 3. Round | 27/08/2021 | RWD Molenbeek | - | Excelsior Virton | 0:0 | ||||
| 4. Round | 11/09/2021 | Excelsior Virton | - | Lommel SK | 2:1 | ||||
| 5. Round | 18/09/2021 | Royal Excel Mouscron | - | Excelsior Virton | 1:1 |  |
|||
| 6. Round | 26/09/2021 | Excelsior Virton | - | KMSK Deinze | 1:1 |  |
|||
| 7. Round | 03/10/2021 | Waasland-Beveren | - | Excelsior Virton | 4:3 | ||||
| 8. Round | 16/10/2021 | Excelsior Virton | - | Lierse Kempenzonen | 2:1 | ||||
| 9. Round | 24/10/2021 | KVC Westerlo | - | Excelsior Virton | 2:0 | ||||
| 10. Round | 29/10/2021 | Excelsior Virton | - | Royal Excel Mouscron | 0:2 | ||||
| 11. Round | 05/11/2021 | Lommel SK | - | Excelsior Virton | 1:3 | |
|||
| 12. Round | 21/11/2021 | Excelsior Virton | - | RWD Molenbeek | 0:2 | ||||
| 15. Round | 12/12/2021 | Excelsior Virton | - | Lierse Kempenzonen | 2:2 | ||||
| 16. Round | 19/12/2021 | KVC Westerlo | - | Excelsior Virton | 1:1 |
Belgium