| 4. Round | 28/08/2021 | FC Wiltz 71 | - | RFCU Luxemburg | 2:3 |  |
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| 10. Round | 23/10/2021 | RFCU Luxemburg | - | US Mondorf | 2:1 | |
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| 11. Round | 07/11/2021 | Etzella Ettelbruck | - | RFCU Luxemburg | 1:2 | ||||
| 12. Round | 21/11/2021 | RFCU Luxemburg | - | FC Differdange 03 | 3:1 | |
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| 13. Round | 28/11/2021 | Victoria Rosport | - | RFCU Luxemburg | 3:1 | |
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| 16. Round | 06/02/2022 | RFCU Luxemburg | - | FC Rodange 91 | 2:1 | ||||
| 17. Round | 13/02/2022 | RM Hamm Benfica | - | RFCU Luxemburg | 2:4 | ||||
| 19. Round | 26/02/2022 | F91 Dudelange | - | RFCU Luxemburg | 1:1 | ||||
| 21. Round | 13/03/2022 | US Hostert | - | RFCU Luxemburg | 1:4 | |
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| 22. Round | 19/03/2022 | RFCU Luxemburg | - | Progrès Niedercorn | 3:3 | ||||
| 23. Round | 02/04/2022 | RFCU Luxemburg | - | Union Titus Pétange | 0:0 | ||||
| 24. Round | 10/04/2022 | US Mondorf | - | RFCU Luxemburg | 2:3 | ||||
| 26. Round | 24/04/2022 | FC Differdange 03 | - | RFCU Luxemburg | 4:0 | ||||
| 28. Round | 07/05/2022 | CS FOLA Esch | - | RFCU Luxemburg | 2:0 |  |
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| 30. Round | 22/05/2022 | Swift Hesperange | - | RFCU Luxemburg | 2:0 |
France