| 1. Round | 14/08/2021 | 1899 Hoffenheim [Youth] | - | 1. FC Kaiserslautern [Youth] | 6:2 |  |
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| 2. Round | 22/08/2021 | 1. FC Kaiserslautern [Youth] | - | Hessen Kassel [Youth] | 1:3 | ||||
| 4. Round | 19/09/2021 | 1. FC Kaiserslautern [Youth] | - | SpVgg Greuther Fürth [Youth] | 3:0 | ||||
| 7. Round | 17/10/2021 | FC-Astoria Walldorf [Youth] | - | 1. FC Kaiserslautern [Youth] | 4:2 | ||||
| 8. Round | 23/10/2021 | 1. FC Kaiserslautern [Youth] | - | FC Ingolstadt 04 [Youth] | 2:0 | ||||
| 9. Round | 31/10/2021 | SpVgg Unterhaching [Youth] | - | 1. FC Kaiserslautern [Youth] | 3:0 | |
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| 11. Round | 27/11/2021 | 1. FC Kaiserslautern [Youth] | - | Stuttgarter Kickers [Youth] | 5:3 | ||||
| 12. Round | 04/12/2021 | SV Darmstadt 98 [Youth] | - | 1. FC Kaiserslautern [Youth] | 1:3 |
Luxembourg