| 1. Round | 09/03/2025 | San Antonio FC | - | Monterey Bay FC | 1:0 |  |
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| 2. Round | 16/03/2025 | San Antonio FC | - | Pittsburgh Riverhounds | 2:0 | ||||
| 3. Round | 23/03/2025 | Oakland Roots | - | San Antonio FC | 1:2 |  |
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| 4. Round | 29/03/2025 | Lexington SC | - | San Antonio FC | 2:3 | ||||
| 5. Round | 06/04/2025 | San Antonio FC | - | Phoenix Rising | 1:2 | ||||
| 6. Round | 13/04/2025 | San Antonio FC | - | Miami FC | 1:2 | ||||
| 7. Round | 24/04/2025 | San Antonio FC | - | Colorado Springs Switchbacks | 3:2 | |
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| 8. Round | 03/05/2025 | Rhode Island FC | - | San Antonio FC | 0:0 | ||||
| 9. Round | 11/05/2025 | San Antonio FC | - | Oakland Roots | 1:2 | ||||
| 10. Round | 18/05/2025 | Charleston Battery | - | San Antonio FC | 4:0 |
Portugal