| 3. Round | 22/08/2021 | FC Differdange 03 | - | CS FOLA Esch | 1:1 | ||||
| 5. Round | 11/09/2021 | CS FOLA Esch | - | Progrès Niedercorn | 2:0 | ||||
| 4. Round | 15/09/2021 | CS FOLA Esch | - | Victoria Rosport | 4:4 | ||||
| 6. Round | 19/09/2021 | UNA Strassen | - | CS FOLA Esch | 2:2 |  |
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| 7. Round | 22/09/2021 | CS FOLA Esch | - | Swift Hesperange | 2:1 | ||||
| 8. Round | 26/09/2021 | FC Rodange 91 | - | CS FOLA Esch | 1:2 | ||||
| 9. Round | 17/10/2021 | CS FOLA Esch | - | RM Hamm Benfica | 2:1 |  |
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| 11. Round | 06/11/2021 | CS FOLA Esch | - | F91 Dudelange | 0:3 | ||||
| 12. Round | 21/11/2021 | Jeunesse Esch | - | CS FOLA Esch | 3:3 |  |
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| 13. Round | 28/11/2021 | CS FOLA Esch | - | US Hostert | 2:0 | ||||
| 14. Round | 04/12/2021 | RFCU Luxemburg | - | CS FOLA Esch | 0:1 | |
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| 15. Round | 11/12/2021 | CS FOLA Esch | - | Union Titus Pétange | 3:0 |
Portugal