| 12. Round | 03/10/2021 | CF América | - | Pumas UNAM | 2:0 | ||||
| 13. Round | 17/10/2021 | Pumas UNAM | - | FC Juárez | 1:0 | ||||
| 14. Round | 21/10/2021 | Club León | - | Pumas UNAM | 1:2 |  |
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| 15. Round | 24/10/2021 | Pumas UNAM | - | Club Tijuana | 3:1 | ||||
| 16. Round | 31/10/2021 | CF Pachuca | - | Pumas UNAM | 1:1 | ||||
| 11. Round | 05/11/2021 | Pumas UNAM | - | Santos Laguna | 0:3 | ||||
| 17. Round | 07/11/2021 | Pumas UNAM | - | Cruz Azul | 4:3 |  |
Brazil