| 1. Round | 28/07/2020 | Atlético San Luis | - | FC Juárez | 1:1 |  |
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| 4. Round | 13/08/2020 | Club Tijuana | - | Atlético San Luis | 0:2 | ||||
| 5. Round | 15/08/2020 | Deportivo Guadalajara | - | Atlético San Luis | 2:1 | ||||
| 7. Round | 30/08/2020 | Atlético San Luis | - | CF América | 1:2 | ||||
| 10. Round | 13/09/2020 | Pumas UNAM | - | Atlético San Luis | 3:0 | ||||
| 11. Round | 21/09/2020 | Atlético San Luis | - | CF Monterrey | 1:2 | ||||
| 14. Round | 16/10/2020 | Atlético San Luis | - | Gallos Blancos | 2:1 | ||||
| 15. Round | 26/10/2020 | Santos Laguna | - | Atlético San Luis | 2:1 | |
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| 16. Round | 30/10/2020 | Atlético San Luis | - | Mazatlán FC | 0:5 |
Mexico