| 1. Round | 09/07/2016 | Libertad | - | River Plate | 1:1 | ||||
| 2. Round | 15/07/2016 | Deportivo Capiatá | - | Libertad | 0:1 | ||||
| 3. Round | 20/07/2016 | Libertad | - | Cerro Porteño | 1:1 | ||||
| 4. Round | 24/07/2016 | Sol de América | - | Libertad | 4:2 | ||||
| 5. Round | 31/07/2016 | Libertad | - | Club Nacional | 3:0 | ||||
| 7. Round | 15/08/2016 | General Díaz | - | Libertad | 0:1 | ||||
| 9. Round | 28/08/2016 | Club Olimpia | - | Libertad | 1:1 | ||||
| 11. Round | 17/09/2016 | General Caballero ZC | - | Libertad | 1:5 |  |
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| 12. Round | 24/09/2016 | River Plate | - | Libertad | 2:0 | ||||
| 13. Round | 01/10/2016 | Libertad | - | Deportivo Capiatá | 1:1 | ||||
| 14. Round | 15/10/2016 | Cerro Porteño | - | Libertad | 2:1 | ||||
| 15. Round | 22/10/2016 | Libertad | - | Sol de América | 0:0 | ||||
| 16. Round | 30/10/2016 | Club Nacional | - | Libertad | 1:2 | ||||
| 17. Round | 06/11/2016 | Sportivo Luqueño | - | Libertad | 0:2 | ||||
| 19. Round | 27/11/2016 | Guaraní | - | Libertad | 1:3 | ||||
| 20. Round | 04/12/2016 | Libertad | - | Club Olimpia | 2:2 |  |
Paraguay