| 1. Round | 17/01/2020 | River Plate | - | Sol de América | 3:0 |  |
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| 2. Round | 25/01/2020 | Guaireña FC | - | River Plate | 2:0 | ||||
| 4. Round | 07/02/2020 | Libertad | - | River Plate | 2:1 | |
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| 5. Round | 17/02/2020 | River Plate | - | San Lorenzo | 4:2 | |
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| 8. Round | 08/03/2020 | Club Olimpia | - | River Plate | 1:1 | ||||
| 9. Round | 21/07/2020 | River Plate | - | Club Nacional | 1:1 | ||||
| 10. Round | 25/07/2020 | River Plate | - | Cerro Porteño | 0:2 | ||||
| 11. Round | 31/07/2020 | Sportivo Luqueño | - | River Plate | 0:1 | ||||
| 6. Round | 05/08/2020 | Guaraní | - | River Plate | 3:0 | ||||
| 12. Round | 09/08/2020 | Sol de América | - | River Plate | 0:0 | ||||
| 13. Round | 12/08/2020 | River Plate | - | Guaireña FC | 2:1 | ||||
| 16. Round | 26/08/2020 | San Lorenzo | - | River Plate | 0:0 | ||||
| 17. Round | 29/08/2020 | River Plate | - | Guaraní | 1:0 | |
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| 18. Round | 04/09/2020 | 12 de Octubre de Itauguá | - | River Plate | 0:1 | ||||
| 20. Round | 22/09/2020 | Club Nacional | - | River Plate | 1:2 | ||||
| 21. Round | 27/09/2020 | Cerro Porteño | - | River Plate | 3:1 | ||||
| 22. Round | 03/10/2020 | River Plate | - | Sportivo Luqueño | 0:0 |
Paraguay