| 1. Round | 18/10/2020 | River Plate | - | 12 de Octubre de Itauguá | 1:2 | ||||
| 3. Round | 01/11/2020 | River Plate | - | Guaraní | 1:0 | ||||
| 4. Round | 07/11/2020 | Libertad | - | River Plate | 3:1 | ||||
| 5. Round | 10/11/2020 | River Plate | - | Guaireña FC | 1:2 |  |
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| 6. Round | 15/11/2020 | Sol de América | - | River Plate | 2:3 | ||||
| 7. Round | 20/11/2020 | River Plate | - | Cerro Porteño | 1:2 | |
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| 8. Round | 28/11/2020 | Club Olimpia | - | River Plate | 3:1 | ||||
| 9. Round | 05/12/2020 | General Díaz | - | River Plate | 0:0 |  |
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| 10. Round | 12/12/2020 | River Plate | - | Club Nacional | 1:1 | ||||
| 11. Round | 18/12/2020 | San Lorenzo | - | River Plate | 0:0 |
Paraguay