| 1. Round | 15/09/2000 | PS Kalamata | - | PAOK Saloniki | 0:0 | ||||
| 2. Round | 23/09/2000 | PAS Giannina | - | PAOK Saloniki | 1:3 | ||||
| 4. Round | 31/10/2000 | Aris Saloniki | - | PAOK Saloniki | 4:0 | ||||
| 5. Round | 04/11/2000 | PAOK Saloniki | - | OFI Heraklion | 4:1 | ||||
| 6. Round | 11/11/2000 | Paniliakos Pyrgos | - | PAOK Saloniki | 1:1 | ||||
| 7. Round | 17/11/2000 | PAOK Saloniki | - | Panathinaikos | 2:2 | ||||
| 14. Round | 13/01/2001 | PAOK Saloniki | - | AEK Athen | 2:1 | ||||
| 15. Round | 20/01/2001 | Panachaiki GE | - | PAOK Saloniki | 1:2 | ||||
| 17. Round | 03/02/2001 | PAOK Saloniki | - | PAS Giannina | 2:3 | ||||
| 22. Round | 09/03/2001 | Panathinaikos | - | PAOK Saloniki | 5:2 | ||||
| 25. Round | 07/04/2001 | Iraklis Saloniki | - | PAOK Saloniki | 1:1 | ||||
| 26. Round | 21/04/2001 | PAOK Saloniki | - | Athinaikos | 3:1 | ||||
| 27. Round | 28/04/2001 | Ethnikos Asteras | - | PAOK Saloniki | 3:3 |
Greece