| 3. Round | 17/06/2021 | New York RB II | - | Charlotte Independence | 3:1 | ||||
| 3. Round | 24/06/2021 | Charlotte Independence | - | Charleston Battery | 3:0 | ||||
| 4. Round | 11/07/2021 | Charlotte Independence | - | Phoenix Rising | 1:1 | ||||
| 4. Round | 01/08/2021 | Charlotte Independence | - | Tampa Bay Rowdies | 2:0 | ||||
| 5. Round | 11/08/2021 | New York RB II | - | Charlotte Independence | 2:3 | ||||
| 5. Round | 15/08/2021 | Charlotte Independence | - | Pittsburgh Riverhounds | 1:0 | ||||
| 5. Round | 22/08/2021 | Charlotte Independence | - | Colorado Springs Switchbacks | 3:3 | ||||
| 6. Round | 19/09/2021 | Charlotte Independence | - | Pittsburgh Riverhounds | 1:0 |
France