| 1. Round | 18/07/2021 | Khimik Dzerzhinsk | - | Enisey Krasnoyarsk 2 | 0:1 | ||||
| 2. Round | 24/07/2021 | Khimik Dzerzhinsk | - | FK Chertanovo | 0:0 | ||||
| 4. Round | 07/08/2021 | Khimik Dzerzhinsk | - | Olimp-Dolgoprudny 2 | 2:0 | ||||
| 5. Round | 15/08/2021 | Torpedo Vladimir | - | Khimik Dzerzhinsk | 1:1 | ||||
| 6. Round | 21/08/2021 | Khimik Dzerzhinsk | - | FK Kazanka Moskva | 1:2 | ||||
| 12. Round | 26/09/2021 | FK Chertanovo | - | Khimik Dzerzhinsk | 1:0 | ||||
| 14. Round | 04/10/2021 | Olimp-Dolgoprudny 2 | - | Khimik Dzerzhinsk | 1:1 |  |
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| 15. Round | 10/10/2021 | Khimik Dzerzhinsk | - | Torpedo Vladimir | 0:0 | ||||
| 16. Round | 14/10/2021 | FK Kazanka Moskva | - | Khimik Dzerzhinsk | 2:1 | ||||
| 17. Round | 19/10/2021 | Khimik Dzerzhinsk | - | Dinamo Moskva 2 | 0:1 | ||||
| 18. Round | 25/10/2021 | FK Murom | - | Khimik Dzerzhinsk | 1:1 |
Russia