| 20. Round | 07/03/2022 | FK Yessentuki | - | Spartak Nalchik | 0:0 |  |
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| 22. Round | 21/03/2022 | FK Yessentuki | - | Anzhi Makhachkala | 0:0 | ||||
| 23. Round | 27/03/2022 | FK Druzhba | - | FK Yessentuki | 0:0 | ||||
| 24. Round | 04/04/2022 | FK Yessentuki | - | Alania-2 Vladikavkaz | 2:1 | ||||
| 25. Round | 10/04/2022 | Kuban-Holding Pavlovskaya | - | FK Yessentuki | 4:1 | ||||
| 26. Round | 18/04/2022 | FK Yessentuki | - | Forte Taganrog | 2:3 | ||||
| 27. Round | 23/04/2022 | FK Dinamo Makhachkala | - | FK Yessentuki | 5:0 | ||||
| 28. Round | 29/04/2022 | FK Yessentuki | - | Rotor-2 Volgograd | 0:2 | ||||
| 29. Round | 06/05/2022 | FK Tuapse | - | FK Yessentuki | 3:0 | ||||
| 30. Round | 12/05/2022 | FK Yessentuki | - | FK SKA Rostov | 1:2 | ||||
| 32. Round | 23/05/2022 | FK Yessentuki | - | Chernomorets Novorossisk | 0:6 | ||||
| 34. Round | 05/06/2022 | FK Biolog Novokubansk | - | FK Yessentuki | 3:1 |
Russia