| 7. Round | 04/09/2021 | FK Yessentuki | - | FK Druzhba | 2:1 | ||||
| 8. Round | 08/09/2021 | Alania-2 Vladikavkaz | - | FK Yessentuki | 1:1 |  |
|||
| 9. Round | 13/09/2021 | FK Yessentuki | - | Kuban-Holding Pavlovskaya | 1:2 | ||||
| 14. Round | 17/10/2021 | FK SKA Rostov | - | FK Yessentuki | 1:0 | |
|||
| 15. Round | 22/10/2021 | FK Yessentuki | - | Dinamo Stavropol | 0:3 | ||||
| 19. Round | 27/10/2021 | FK Mashuk KMV | - | FK Yessentuki | 7:0 | ||||
| 16. Round | 31/10/2021 | Chernomorets Novorossisk | - | FK Yessentuki | 5:0 | ||||
| 18. Round | 12/11/2021 | FK Yessentuki | - | FK Legion Dynamo Makhachkala | 0:6 |
Russia