| 1. Round | 18/07/2021 | Salyut Belgorod | - | Zenit Penza | 3:1 | ||||
| 2. Round | 24/07/2021 | Zenit Penza | - | Sokol Saratov | 0:2 | ||||
| 3. Round | 01/08/2021 | Avangard Kursk | - | Zenit Penza | 4:0 | ||||
| 4. Round | 07/08/2021 | Zenit Penza | - | Fakel Voronezh 2 | 2:1 |  |
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| 10. Round | 14/09/2021 | Arsenal Tula 2 | - | Zenit Penza | 1:0 |  |
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| 15. Round | 10/10/2021 | Zenit Penza | - | Avangard Kursk | 3:1 | ||||
| 18. Round | 25/10/2021 | FK Ryazan | - | Zenit Penza | 3:1 |
Russia