| 1. Round | 24/07/2021 | FK Yessentuki | - | FK Biolog Novokubansk | 0:5 | ||||
| 2. Round | 01/08/2021 | FK Legion Dynamo Makhachkala | - | FK Yessentuki | 3:1 |  |
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| 3. Round | 06/08/2021 | FK Yessentuki | - | FK Mashuk KMV | 0:2 | ||||
| 4. Round | 15/08/2021 | Spartak Nalchik | - | FK Yessentuki | 2:1 | ||||
| 5. Round | 20/08/2021 | FK Yessentuki | - | FK Chayka | 1:9 | ||||
| 6. Round | 30/08/2021 | Anzhi Makhachkala | - | FK Yessentuki | 5:0 | ||||
| 10. Round | 18/09/2021 | Forte Taganrog | - | FK Yessentuki | 6:0 | ||||
| 11. Round | 27/09/2021 | FK Yessentuki | - | FK Dinamo Makhachkala | 0:2 | ||||
| 14. Round | 17/10/2021 | FK SKA Rostov | - | FK Yessentuki | 1:0 | ||||
| 15. Round | 22/10/2021 | FK Yessentuki | - | Dinamo Stavropol | 0:3 |
Russia