| 1. Round | 20/07/2021 | Irtysh Omsk | - | Zenit Izhevsk | 2:1 | ||||
| 2. Round | 23/07/2021 | Irtysh Omsk | - | FK Amkar Perm | 1:2 | ||||
| 3. Round | 04/08/2021 | Nosta Novotroitsk | - | Irtysh Omsk | 1:4 |  |
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| 4. Round | 07/08/2021 | FK Orenburg 2 | - | Irtysh Omsk | 1:1 | ||||
| 5. Round | 18/08/2021 | Irtysh Omsk | - | Zvezda Perm | 1:0 | ||||
| 6. Round | 21/08/2021 | Irtysh Omsk | - | FK Tyumen | 2:4 | ||||
| 7. Round | 02/09/2021 | FK Ural 2 | - | Irtysh Omsk | 1:1 |  |
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| 11. Round | 27/09/2021 | Lada Tolyatti | - | Irtysh Omsk | 2:2 | ||||
| 12. Round | 30/09/2021 | Volga Ulyanovsk | - | Irtysh Omsk | 6:1 | ||||
| 13. Round | 13/10/2021 | Irtysh Omsk | - | FK Novosibirsk | 3:1 | ||||
| 15. Round | 17/10/2021 | Dinamo Barnaul | - | Irtysh Omsk | 1:1 | |
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| 16. Round | 20/10/2021 | FK Novosibirsk | - | Irtysh Omsk | 2:0 | |
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| 17. Round | 30/10/2021 | Irtysh Omsk | - | Dinamo Barnaul | 2:0 | |
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| 19. Round | 09/11/2021 | Irtysh Omsk | - | Volga Ulyanovsk | 3:3 | |
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| 22. Round | 10/04/2022 | Spartak Tuymazy | - | Irtysh Omsk | 0:6 | |
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| 21. Round | 13/04/2022 | Torpedo Miass | - | Irtysh Omsk | 2:0 | ||||
| 24. Round | 24/04/2022 | Irtysh Omsk | - | FK Ural 2 | 2:2 | ||||
| 27. Round | 18/05/2022 | Irtysh Omsk | - | FK Orenburg 2 | 1:1 | ||||
| 29. Round | 01/06/2022 | FK Amkar Perm | - | Irtysh Omsk | 2:0 |
Russia