| 1. Round | 12/03/2021 | FK Isloch Minsk | - | FK Slaviya Mozyr | 1:0 | ||||
| 2. Round | 19/03/2021 | FK Isloch Minsk | - | FK Smorgon | 2:0 | ||||
| 3. Round | 03/04/2021 | Shakhter Soligorsk | - | FK Isloch Minsk | 4:0 | ||||
| 4. Round | 10/04/2021 | FK Isloch Minsk | - | Rukh Brest | 0:1 | ||||
| 5. Round | 16/04/2021 | Sputnik Rechytsa | - | FK Isloch Minsk | 1:5 | ||||
| 6. Round | 25/04/2021 | FK Isloch Minsk | - | BATE Borisov | 1:4 | ||||
| 7. Round | 01/05/2021 | Neman Grodno | - | FK Isloch Minsk | 1:2 | ||||
| 9. Round | 15/05/2021 | Torpedo-BelAZ Zhodino | - | FK Isloch Minsk | 3:3 | ||||
| 10. Round | 19/05/2021 | FK Isloch Minsk | - | FK Vitebsk | 0:1 | ||||
| 13. Round | 19/06/2021 | FK Gomel | - | FK Isloch Minsk | 2:0 | ||||
| 14. Round | 27/06/2021 | FK Isloch Minsk | - | FK Minsk | 1:1 | ||||
| 15. Round | 03/07/2021 | Energetik-BGU Minsk | - | FK Isloch Minsk | 1:1 | ||||
| 28. Round | 07/11/2021 | FK Isloch Minsk | - | FK Gomel | 1:2 | ||||
| 29. Round | 20/11/2021 | FK Minsk | - | FK Isloch Minsk | 1:0 | ||||
| 30. Round | 28/11/2021 | FK Isloch Minsk | - | Energetik-BGU Minsk | 0:4 |
Belarus